Thermo Fisher Scientific LL37 Polyclonal Antibody
Rabbit polyclonal antibody against Cathelicidin antimicrobial peptide LL-37. Suitable for WB and IHC applications. Lyophilized form, reconstitutable in sterile water. For research use only, not for diagnostic procedures.
- 카탈로그번호
- OSC00132G-500UG
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Reptile |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from Bungarus fasciatus Cathelicidin antimicrobial peptide (CAP-18, hCAP-18, antibacterial protein LL-37, CAMP, CRAMP) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Cathelicidin antimicrobial peptide.
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes in bone marrow, testis, and neutrophils.
Cathelicidins are a family of antimicrobial peptides characterized by conserved pro-peptide sequences identified in epithelial tissues and certain myeloid cells of humans and animals.
LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. These molecules are essential for defense against invasive bacterial infection in skin.
Beyond direct antimicrobial activity, Cathelicidins play multiple roles in innate and adaptive immunity, including:
- Endotoxin neutralization
- Angiogenesis
- Wound healing
- Promotion of neutrophil chemotaxis and mast cell recruitment
Cathelicidin antimicrobial peptides serve as prototypes for innovative drugs that may treat infection and/or modulate immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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