Thermo Fisher Scientific CD123 Monoclonal Antibody (5B11), PE, eBioscience
마우스 CD123(IL-3 수용체 α사슬)을 인식하는 5B11 클론 단일클론 항체로, PE 형광 표지되어 Flow Cytometry 분석에 적합. 0.5 µg/test로 사용 가능하며, 4°C 암소 보관. IL-3 신호전달 연구 및 AML 관련 표적 분석에 활용 가능.
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Thermo Fisher Scientific CD123 Monoclonal Antibody (5B11), PE, eBioscience
Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 0.5 µg/test
A test is defined as the amount of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically (10⁵–10⁸ cells/test).
The antibody should be titrated for optimal performance.
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B11 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465838 |
Additional Formats
Product Specific Information
The 5B11 monoclonal antibody reacts with mouse CD123, the alpha chain of the IL-3 receptor. This 60–70 kDa transmembrane protein binds IL-3 with low affinity alone, and with high affinity when associated with CD131 (common beta chain) or AIC2A (IL-3β). CD123 requires the beta chain for intracellular signal transduction.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Mouse bone marrow cells at ≤0.5 µg/test
- Excitation: 488–561 nm
- Emission: 578 nm
- Laser Compatibility: Blue, Green, Yellow-Green lasers
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-3Ra (Interleukin-3 receptor subunit alpha) is part of the type I cytokine receptor family. It forms a heterodimer with the common beta (CDw131) subunit to transmit IL-3 signaling. IL-3Ra overexpression has been observed in acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells, making it a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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