Thermo Fisher Scientific STAT1 Polyclonal Antibody
STAT1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 IHC에 적합합니다. 고순도(>95%) 항체이며 Human 및 Rat에 반응합니다. 항원 친화 크로마토그래피로 정제되어 안정적인 신뢰성을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 150–200 of Human STAT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803174 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
STAT1 (Signal Transducers and Activators of Transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune response, and lipid metabolism, and plays a crucial role in cell viability under various stimuli and pathogen exposure.
The STAT1 gene is located on chromosome 2 and becomes activated through phosphorylation by JAK tyrosine kinases. Activated STAT1 enters the nucleus to regulate transcription of various genes. Among the seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have broad activation profiles. STAT1 is activated by ligands such as IFN family (IFN-Alpha, IFN-Beta, IFN-Gamma, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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