Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (ICO-92)

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent
• View 4 publications

Inhibition Assays (IA)

• Tested Dilution: —
• View 1 publication

Product Specifications

Product Specific Information

• MA1-7657 detects Transferrin receptor from human samples.
• MA1-7657 has been successfully used in flow cytometry procedures.
• The immunogen is a Transferrin receptor on activated T-B-cells.

Target Information

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome, and in HIV patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.