Thermo Fisher Scientific CD74 Monoclonal Antibody (3D7), FITC

Applications and Tested Dilution

Product Specifications

Additional Formats

• APC: MA5-45381
• PerCP: MA5-45383
• Custom conjugation available upon request

Product Specific Information

A 1:1,000 dilution of MA5-45382 was sufficient for detection of CD74 in 15 µg of B-Cell Lymphoma cell line Raji by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody. Detects approximately 33 kDa protein.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane and cytoplasmic domains.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, with polymorphisms residing in the beta chain. HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
These molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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