Thermo Fisher Scientific CD74 Monoclonal Antibody (3D7), FITC
Thermo Fisher Scientific의 CD74 Monoclonal Antibody (3D7), FITC는 인간 CD74 단백질을 특이적으로 인식하는 마우스 IgG1 항체입니다. Western blot과 유세포분석에 적합하며, FITC 형광 표지로 498/517 nm에서 검출됩니다. 단백질 G로 정제된 액상 형태로 제공됩니다.
- 카탈로그번호
- MA545382
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D7 |
| Immunogen | Human CD74 invariant chain synthetic peptide |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.09 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931836 |
Additional Formats
- APC: MA5-45381
- PerCP: MA5-45383
- Custom conjugation available upon request
Product Specific Information
A 1:1,000 dilution of MA5-45382 was sufficient for detection of CD74 in 15 µg of B-Cell Lymphoma cell line Raji by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody. Detects approximately 33 kDa protein.
Target Information
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane and cytoplasmic domains.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, with polymorphisms residing in the beta chain. HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
These molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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