Thermo Fisher Scientific p19ARF Polyclonal Antibody
Thermo Fisher Scientific의 p19ARF Polyclonal Antibody는 마우스 및 랫트 시료에서 p19ARF 단백질을 검출하는 데 사용됩니다. Western blot에 최적화되어 있으며, 0.3–1 µg/mL 농도로 권장됩니다. 고순도 정제 및 안정적 보관이 가능한 항체입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-RRGPHRNPGPGDDD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933474 |
Product Specific Information
- This antibody is expected to recognize isoform p19ARF (NP_034007.1) only.
- Tested in Peptide ELISA with antibody detection limit dilution of 1:64,000.
Target Information
In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as inhibitors of cell proliferation, their mechanisms differ.
p19ARF functions as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors, indicating its critical role as a tumor suppressor.
Additionally, p19ARF helps prevent transforming signals from various oncoproteins via the p53 regulatory loop. These findings highlight the importance of p19ARF in cell cycle control and tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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