Thermo Fisher Scientific RUNX2 Recombinant Rabbit Monoclonal Antibody (6H4L27)

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000
• View 1 publication

Product Specifications

Additional Formats

• Alexa Fluor Plus 488
• Alexa Fluor Plus 555
• Alexa Fluor Plus 647
• Request custom conjugation

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Mouse, and Rat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits and screen individual clones to select the best candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

RUNX2 is a nuclear protein and a member of the RUNX family of transcription factors containing a Runt DNA-binding domain. It is essential for membranous and endochondral bone formation, regulating osteoblastic differentiation and skeletal morphogenesis. RUNX2 acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.
It binds DNA as a monomer or more strongly as part of a heterodimeric complex. RUNX2 enhances TGFBR1 expression in osteoblasts and cooperates with DLX5 or related factors to activate osteoblast-specific gene expression.
Mutations in RUNX2 can lead to bone development disorders such as cleidocranial dysplasia (CCD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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