Thermo Fisher Scientific DOK7 Monoclonal Antibody (OTI5C6), TrueMAB
인간 DOK7 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB 및 IHC(P) 검증 완료. 무보존제, 동결건조 형태로 제공되며 재구성 및 결합 실험에 적합. 신경근 시냅스 형성 관련 연구용으로 사용.
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Thermo Fisher Scientific DOK7 Monoclonal Antibody (OTI5C6), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C6 |
| Immunogen | Full length human recombinant protein of human DOK7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The DOK7 protein is essential for neuromuscular synaptogenesis. It functions in aneural activation of muscle-specific receptor kinase (MuSK), required for postsynaptic differentiation and clustering of the acetylcholine receptor in myotubes.
Mutations in DOK7 are associated with familial limb-girdle myasthenia autosomal recessive (congenital myasthenic syndrome type 1B).
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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