Thermo Fisher Scientific DOK7 Monoclonal Antibody (OTI2C12), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The DOK7 gene encodes a protein essential for neuromuscular synaptogenesis. It functions in aneural activation of muscle-specific receptor kinase (MuSK), required for postsynaptic differentiation and acetylcholine receptor clustering in myotubes. DOK7 also induces MuSK autophosphorylation. Mutations in DOK7 cause familial limb-girdle myasthenia autosomal recessive (congenital myasthenic syndrome type 1B). Alternative splicing yields multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.