Thermo Fisher Scientific Phospho-Chk2 (Thr387) Polyclonal Antibody
Phospho-Chk2 (Thr387) 폴리클로날 항체로 인산화된 Chk2 단백질을 특이적으로 검출. Western blot, IHC, ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 항체로 -20°C 보관.
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Thermo Fisher Scientific Phospho-Chk2 (Thr387) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CHEK2 (Accession O96017), corresponding to amino acid residues around phosphorylated Thr387 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816186 |
Product Specific Information
Antibody detects endogenous levels of Chk2 only when phosphorylated at Threonine 387.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in the Chk2 gene linked to Li-Fraumeni syndrome, a familial cancer associated with inherited mutations in TP53. Mutations in CHK2 are also thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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