Thermo Fisher Scientific Phospho-MSK1 (Ser212) Polyclonal Antibody
MSK1 단백질의 Ser212 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. Human 및 Mouse 반응성. 액상 형태로 1 mg/mL 농도, PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RPS6KA5 (Accession O75582), corresponding to amino acid residues around phosphorylated Ser212 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816184 |
Product Specific Information
Antibody detects endogenous levels of MSK1 only when phosphorylated at Serine 212.
Target Information
RPS6KA5 (MSK1) is a serine/threonine protein kinase that plays an essential role in regulating various cellular processes. It is required for mitogen- or stress-induced phosphorylation of transcription factors such as CREB1 and ATF1, and regulates RELA, STAT3, and ETV1/ER81.
MSK1 contributes to gene activation through histone phosphorylation and regulates inflammatory gene expression. It phosphorylates CREB1 and ATF1 in response to stimuli like UV-C irradiation, EGF, and anisomycin.
In skeletal myoblasts, MSK1 is required for RELA phosphorylation at Ser-276 during oxidative stress, and in erythropoietin-stimulated cells, it mediates Ser-727 phosphorylation of STAT3, influencing its transcriptional potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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