Thermo Fisher Scientific CD66e (CEA) Recombinant Rabbit Monoclonal Antibody (JM93-28)
CD66e(CEA) 항원을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체로, 높은 특이성과 재현성을 제공. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 동물 유래 성분이 없는 포뮬레이션으로 일관된 품질 보장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM93-28 |
| Immunogen | Human Carcinoembryonic Antigen (CEA) purified from human liver (aa 1–117) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810030 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits and screen individual clones to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
CEA (Carcinoembryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors. It belongs to the immunoglobulin supergene family, consisting of one N domain and six constant-like domains (A1–A3, B1–B3).
Antibodies to CEA help identify the origin of metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (CEA+) from pleural mesotheliomas (rarely CEA+).
CEA is a glycoprotein tumor marker found in adenocarcinomas of endodermally derived digestive epithelium and fetal colon. Its gene cluster on chromosome 19 includes CEA cell adhesion molecules and pregnancy-specific glycoproteins, along with pseudogenes.
The encoded protein mediates cell adhesion and is involved in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation. Multiple transcript variants exist, but not all are fully defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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