Thermo Fisher Scientific RENT1 Polyclonal Antibody
Western blot에 최적화된 RENT1(UPF1) 폴리클로날 항체로, Human 및 Mouse 시료에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 4°C 보관, 1년의 권장 유효기간을 가집니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 250 and 300 of Human Regulator of Nonsense Transcripts 1 (UPF1, UniProt ID: Q92900-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Upf1 is an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons.
Upf1 functions as an ATP-dependent RNA helicase in the cytoplasm and is a component of cytoplasmic P-bodies.
Phosphorylation of Upf1 mediates translation repression associated with NMD, facilitating mRNA accessibility to the NMD machinery.
Other key NMD components include Upf2 and Upf3, which exhibit perinuclear and nucleocytoplasmic localization, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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