Thermo Fisher Scientific P-Selectin Monoclonal Antibody (AK-6)
P-Selectin(CD62P)을 인식하는 마우스 단클론 항체(AK-6)로, 인간 및 원숭이 반응성을 보입니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용됩니다. 단백질 A로 정제된 액상 항체이며, PBS 버퍼에 보존제 없이 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:10–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rhesus monkey |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AK-6 |
| Immunogen | Human platelet membrane glycoproteins (Target: P-Selectin (CD62P), UniProt ID: P16109-1, Antigen range: 1–830) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538074 |
Additional Formats
Product Specific Information
- For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
- A suggested positive control for immunohistochemical applications is human tonsil.
- Mouse anti-Human CD62P antibody, clone AK-6 recognizes CD62P (P-selectin), also known as Granule membrane protein 140 (GMP140), Leukocyte-endothelial cell adhesion molecule 3 (LECAM3), or Platelet activation-dependent granule-external membrane protein.
Target Information
P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein that regulates cell rolling. It is stored in the Weibel-Palade bodies of endothelial cells and α-granules of platelets and is rapidly translocated to the cell surface upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP.
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, playing a key role in leukocyte-endothelial adhesion. It binds to sialylated Lewis carbohydrate antigens on neutrophils and monocytes in a calcium-dependent manner.
P-selectin expression is associated with inflammation, atherogenesis, thrombosis, and tissue injury. Clinically, it aids in distinguishing heparin-induced thrombocytopenia with or without thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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