Thermo Fisher Scientific TCF7 Polyclonal Antibody
TCF7 단백질 검출용 Rabbit Polyclonal Antibody로 Western blot 및 Immunohistochemistry에 최적화됨. Human TCF7 C-terminal 펩타이드(aa 284–384)를 면역원으로 제작. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TCF7 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the C-terminal of Human TCF7 (284–384 aa), conjugated to Keyhole Limpet Haemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736689 |
Product Specific Information
A 1:1,000 dilution of PA5-77813 was sufficient for detection of TCF7 in 15 µg of human HeLa cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. Detects 42 kDa; an additional band at approximately 54 kDa represents another isoform.
Target Information
TCF7 (Transcriptional Factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. It is necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms of TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as a feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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