Thermo Fisher Scientific MFN2 Polyclonal Antibody
MFN2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 IHC(파라핀 절편)에 사용 가능. 인간, 마우스, 랫트에 반응하며, 항원 친화 크로마토그래피로 정제됨. 미토콘드리아 융합 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–183 of Human MFN2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7) with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545082 |
Product Specific Information
- Recommended positive control: MFN2-transfected 293T cells
- Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (83%), Xenopus laevis (82%), Dog (99%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The MFN2 gene encodes a mitochondrial membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial network. It regulates vascular smooth muscle cell proliferation and may play a role in obesity pathophysiology.
Mutations in MFN2 cause Charcot-Marie-Tooth disease type 2A2 and hereditary motor and sensory neuropathy VI, both affecting the peripheral nervous system. Defects have also been linked to early-onset stroke. Two transcript variants encoding the same protein have been identified.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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