Thermo Fisher Scientific MMP25 Polyclonal Antibody
MMP25 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며 Human, Mouse, Rat 시료에서 반응합니다. 고순도 Affinity Chromatography 정제, 안정적인 PBS/glycerol buffer 제공.
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Thermo Fisher Scientific MMP25 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 321–539 of human MMP25 (NP_0719131) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.62 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806238 |
Product Specific Information
Immunogen Sequence:
FDAIANIRGE TFFFKGPWFW RLQPSGQLVS PRPARLHRFW EGLPAQVRVV QAAYARHRDG RILLFSGPQF WVFQDRQLEG GARPLTELGL PPGEEVDAVF SWPQNGKTYL VRGRQYWRYD EAAARPDPGY PRDLSLWEGA PPSPDDVTVS NAGDTYFFKG AHYWRFPKNS IKTEPDAPQP MGPNWLDCPA PSSGPRAPRP PKATPVSETC DCQCELNQA
Positive Samples:
A-549, HT-29, Mouse lung, Mouse liver, Rat liver
Cellular Location:
Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Extracellular matrix, Extracellular space
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes like arthritis and metastasis.
Most MMPs are secreted as inactive proproteins that are activated upon cleavage by extracellular proteinases.
MMP25 is a membrane-type MMP (MT-MMP) attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor.
In response to bacterial infection or inflammation, it inactivates alpha-1 proteinase inhibitor, facilitating neutrophil migration to inflammatory sites.
It may also play a role in tumor invasion and metastasis through activation of MMP2.
The gene was previously referred to as MMP20 but has been renamed MMP25.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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