Thermo Fisher Scientific Phospho-MAPK15 (Thr175, Tyr177) Polyclonal Antibody
MAPK15의 Thr175 및 Tyr177 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB 및 ICC/IF에 적합합니다. 액상 형태이며 1 mg/mL 농도, -20°C 보관. 세포 성장 및 분화 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ERK8 around the phosphorylation site of Thr175 and Tyr177 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2902995 |
Target Information
The ERKs are a subfamily of MAPKs implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase regulated by serum and the c-Src non-receptor tyrosine kinase.
ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in nuclear receptor regulation beyond estrogen receptor alpha.
Erk8 is also a novel effector of RET/PTC3 and therefore involved in RET biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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