Thermo Fisher Scientific ELOVL6 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL
• View 1 publication

Immunohistochemistry (IHC)

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

• Suggested positive control: human brain tissue lysate
• PA5-20520 can be used with blocking peptide PEP-0640.

Target Information

Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1.
Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of the fatty acyl-CoA elongase gene family that converts palmitic to stearic acid.
It is a target of SREBP-1 and plays an important role in de novo synthesis of long-chain saturated and monounsaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase.
ELOVL6 is predicted to be important for tissue fatty acid composition.
Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes, and cardiovascular risks, even in the presence of obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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