Thermo Fisher Scientific RIM2 Polyclonal Antibody
RIM2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB 및 IHC에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. 신경전달 및 시냅스 연구용으로 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the center of the human Rim2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at −20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153209 |
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-20522 can be used with blocking peptide PEP-0642.
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca²⁺ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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