Thermo Fisher Scientific NPTX2 Polyclonal Antibody
NPTX2 단백질을 검출하기 위한 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. WB 및 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 신경 관련 연구 및 파킨슨병 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the center of the human NPTX2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152121 |
Product Specific Information
- Suggested positive control: Mouse brain tissue lysate
- PA5-20521 can be used with blocking peptide PEP-0641
Target Information
Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family with high homology to NPTX1. Unlike NPTX1, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle, and brain. It possesses lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity.
NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis.
NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson’s disease (PD), suggesting involvement in PD-related pathway dysregulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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