Thermo Fisher Scientific INPP5J Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) [IHC (P)]: 10–15 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• 100%: Human, Gorilla, Monkey, Elephant, Horse, Pig
• 95%: Gibbon, Marmoset, Mouse, Rat, Bovine, Dog, Hamster, Panda, Rabbit
• 89%: Bat, Platypus

For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

Inositol and phosphatidylinositol phosphates are crucial for numerous cellular processes, including neuronal survival and signal transduction from growth factors, neurotransmitters, and G protein-coupled receptors.
INPP5J (inositol polyphosphate-5-phosphatase J), also known as phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, PIPP, PIB5PA, or INPP5, is a 1,006 amino acid cytoplasmic protein that assists in the conversion of inositol 1,4-bisphosphate from inositol 1,4,5-trisphosphate.
Expressed in lung, stomach, kidney, brain, small intestine, and heart, INPP5J localizes to membrane ruffles, where it may also participate in modulating inositol and phosphatidylinositol polyphosphate-binding proteins.
Encoded by a gene located on human chromosome 22, INPP5J undergoes alternative splicing to produce three isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.