Thermo Fisher Scientific INPP5J Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

10-15 µg/mL

-

Product Specifications

Species Reactivity

Horse, Human, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 19 amino acid peptide from internal region of human INPP5J / PIB5PA.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550336

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Elephant, Horse, Pig (100%); Gibbon, Marmoset, Mouse, Rat, Bovine, Dog, Hamster, Panda, Rabbit (95%); Bat, Platypus (89%).

For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

Inositol and phosphatidylinositol phosphates are important for numerous cellular processes, including neuronal survival and signal transductions from growth factors, neurotransmitters and G protein coupled receptors. INPP5J (inositol polyphosphate-5-phosphatase J), also known as phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, PIPP (proline-rich inositol polyphosphate 5-phosphatase), PIB5PA or INPP5, is a 1,006 amino acid cytoplasmic protein that assists in the conversion of inositol 1,4-bisphosphate from inositol 1,4,5-trisphosphate. Expressed in lung, stomach, kidney, brain, small intestine and heart, INPP5J localizes to membrane ruffles, where it may also participate in modulating inositol and phosphatidylinositol polyphosphate-binding proteins. Encoded by a gene located on human chromosome 22, INPP5J undergoes alternative splicing to produce three isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.