Thermo Fisher Scientific CD49f Polyclonal Antibody
Rabbit polyclonal antibody targeting human CD49f (Integrin α6). Validated for IHC (paraffin) with 1–5 µg/mL dilution. Cross-reactive with bat and non-human primates. Purified via antigen affinity chromatography, supplied in PBS with 0.1% sodium azide. ...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from N-terminus of human ITGA6 / CD49f |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550344 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Gibbon, Monkey, Marmoset, Bat (100%)
- Mouse, Bovine, Dog, Hamster, Elephant, Panda, Horse (94%)
- Rat (89%)
Target Information
CD49f (Integrin alpha-6, ITGA6) is an integrin alpha chain protein. Integrins are integral cell-surface proteins composed of alpha and beta chains that combine to form various integrins. For example, alpha 6 may pair with beta 4 (TSP180) or beta 1 (VLA-6).
They play roles in cell adhesion and cell-surface mediated signaling. Integrins interact with the extracellular matrix (ECM) and mediate intracellular signals affecting cell shape, mobility, and cell cycle progression.
CD49f is predominantly expressed by epithelial cells and contributes structurally to hemidesmosomes.
More than 18 alpha and 8 beta subunits with numerous splice variants exist in mammals. Certain integrins also bind to soluble ligands or counter-receptors on adjacent cells (e.g., ICAMs), promoting cell aggregation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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