Thermo Fisher Scientific Phospho-C-Myc (Ser373) Polyclonal Antibody
Phospho-C-Myc (Ser373) 폴리클로날 항체로, 인간 및 생쥐 시료에 반응하며 Western blot, IHC, Flow cytometry, ELISA에 적합합니다. 단백질 A로 정제된 액상 항체로, 세포 증식 및 종양 관련 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human C-Myc around the phosphorylation site of Ser373 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays key roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is linked to cell proliferation and regulation.
c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression of c-Myc can induce apoptosis and is associated with numerous cancers including lung, breast, and colon carcinomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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