Thermo Fisher Scientific LYRIC/AEG1 Recombinant Rabbit Monoclonal Antibody (BLR258L)
LYRIC/AEG1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단일클론 항체. Western blot, IHC, ICC/IF, Flow cytometry, IP에 사용 가능. 인간 및 생쥐 반응성. 고순도 정제, 액상 형태로 제공되며 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 |
| Flow Cytometry (Flow) | 1 µL/10⁶ cells |
| Immunoprecipitation (IP) | 20 µL/mg of lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR258L |
| Immunogen | Peptide representing a region between residue 450–500 of Human LYRIC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 250 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
Metadherin (also known as MTDH or LYRIC) is a metastasis adhesion protein localized with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It functions in tight junction maturation rather than as a structural component. Metadherin is overexpressed in breast cancer tissues and xenografts, with lower expression in normal breast tissue. It binds to lung vasculature via a C-terminal extracellular domain segment, and inhibition of this domain or gene silencing has been reported to reduce breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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