Thermo Fisher Scientific Human TGF-beta 3 Recombinant Protein
인간 유래 TGF-beta 3 재조합 단백질로, 세포 신호전달 및 면역 조절 연구에 활용됩니다. E. coli 발현 시스템에서 생산되며, >98% 순도와 낮은 엔도톡신 수준을 보장합니다. 다양한 어세이(WB, IHC, ELISA)에 적용 가능하며 높은 생물학적 활성을 제공합니다.
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human TGF-beta 3 Recombinant Protein
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | Assay-dependent |
| Functional Assay | Assay-dependent |
| Control (Ctrl) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | Human TGF-beta 3 recombinant protein is a homodimer containing two 112 amino acid subunits |
| Molecular Weight | 25.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >98% by SDS-PAGE and HPLC |
| Endotoxin Concentration | <0.1 ng/µg |
| Activity | ED50 ≤ 0.05 ng/mL (≥ 12.5×10⁶ IU/mg); determined by a toxicity assay using the WHO Standard 98/608 for direct comparison |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | 0.12% acetic acid with 20% ethanol |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice (domestic); Wet or Dry ice (international) |
Product Specific Information
- Purity: >98% by SDS-PAGE and HPLC
- Endotoxin Concentration: <0.1 ng/µg
- Protein Length: 112 aa (2 identical subunits)
- Biological Activity: ED50 ≤ 0.05 ng/mL
- Molecular Weight: 17.5 kDa
Target Information
Transforming growth factor beta 3 (TGF-beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF-beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer.
As with all members of the family, TGF-beta 3 is highly conserved across species, with mouse and human TGF-beta 3 demonstrating 100% sequence homology and cross-species activity. Members of this family can be expressed by most cell types and exert pleiotropic effects, including suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation.
Additionally, TGF-beta cytokines promote CD4⁺CD25⁺ T-cell expansion, indicating an important role in protection against autoimmunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.