Thermo Fisher Scientific PIK3CG Monoclonal Antibody (OTI6G5), TrueMAB
Human PIK3CG 단백질을 인식하는 mouse monoclonal antibody로, WB, IHC(P), ICC/IF에 적합. Lyophilized 형태로 제공되며, carrier-free 상태로 conjugation 실험에 유용. Affinity chromatography로 정제되어 높은 순도와 재현성을 보장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G5 |
| Immunogen | Full length human recombinant protein of human PIK3CG produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member that generates the second messenger PIP2. Unlike class IA enzymes that signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs.
This enzyme phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring and modulates extracellular signals, including E-cadherin-mediated cell-cell adhesion, crucial for epithelial integrity.
Additionally, it plays a role in NK cell cytotoxicity regulation. The gene is located in a commonly deleted segment of chromosome 7 associated with myeloid leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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