Thermo Fisher Scientific PIK3CG Monoclonal Antibody (OTI4B9), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

PIK3CG (p110 gamma) is a class IB phosphatidylinositol 3-kinase family member that generates the second messenger PIP2. Unlike class IA enzymes signaling downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs.
This enzyme phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring and modulates extracellular signals, including those from E-cadherin-mediated cell-cell adhesion. It plays a critical role in maintaining epithelial integrity and regulating cytotoxicity in NK cells.
The gene is located in a commonly deleted segment of chromosome 7, previously associated with myeloid leukemias.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.