Thermo Fisher Scientific PSD-95 Recombinant Rabbit Monoclonal Antibody (23H23L19)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Catalog number 700902 has been successfully used in immunofluorescence analysis of PSD-95 in human motor neurons derived from iPSCs.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits and screen individual clones for optimal performance.
Advantages of recombinant rabbit monoclonal antibodies include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse-associated protein 90 kDa (SAP90), is a membrane-associated protein found in the postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum.
PSD-95 contains three PDZ domains, an SH3 domain, and a guanylate kinase-like domain. It plays a critical role in clustering proteins such as NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.

PSD-95 interacts with other proteins through two main mechanisms:

1. NMDA receptors and Shaker-type potassium channels share a C-terminal motif (T/SXV) that binds to PDZ domains of PSD-95.
2. Neuronal nitric oxide synthase (nNOS), which lacks this motif but has its own PDZ domain, associates with PSD-95 via PDZ-PDZ interactions.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.