Thermo Fisher Scientific COL4A3 Polyclonal Antibody

Thermo Fisher Scientific COL4A3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Antibody predicted to react with dog and cow based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

Type IV collagen is the major structural component of basement membranes, composed of three alpha subunits encoded by six different genes (α1–α6). Each can form a triple helix structure to create type IV collagen.
The COL4A3 gene encodes the alpha 3 subunit. In Goodpasture syndrome, autoantibodies bind to collagen molecules in alveoli and glomeruli basement membranes, primarily targeting the non-collagenous C-terminal domain.
A specific kinase phosphorylates amino acids in this C-terminal region, with expression upregulated during pathogenesis.
Mutations in this region are linked to autosomal recessive Alport syndrome. Like other type IV collagen genes, COL4A3 is organized head-to-head with another type IV collagen gene, sharing a common promoter.
(Information provided by RefSeq, Jun 2010.)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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