Thermo Fisher Scientific Spectrin beta-3 Polyclonal Antibody
Spectrin beta-3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 4°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:250 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Residues 2150–2200 of human spectrin, beta, non-erythrocytic 2 (SPTBN2, spinocerebellar ataxia 5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate / Tris phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_2302452 |
Target Information
Spectrins are principal components of the cell membrane-cytoskeleton, composed of two alpha and two beta spectrin subunits.
The protein encoded by SPTBN2 (spectrin beta non-erythrocytic 2 or beta-III spectrin) is related to but distinct from SPTBN1 (beta-II spectrin).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in this gene cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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