Thermo Fisher Scientific TMP21 Polyclonal Antibody
TMP21 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간, 생쥐, 토끼 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제되었으며, PBS/30% 글리세롤 용액에 보관. 알츠하이머 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Non-human primate, Rabbit, Rat, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic internal peptide corresponding to residues 50–150 of the human TMP21 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.95 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2204346 |
Product Specific Information
- Suggested positive control: human liver protein.
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex, modulating the γ-secretase but not the ε-secretase cleavage activity of the amyloid precursor protein (APP).
The presenilin complex includes APH1, nicastrin, and PEN2, which together cleave APP at γ- and ε-sites, potentially leading to the accumulation of the Aβ cleavage product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments have shown that TMP21 interacts with these proteins, suggesting a regulatory role in the complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Aβ production, indicating that TMP21 modulates γ-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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