Thermo Fisher Scientific TMP21 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control: human liver protein.

Target Information

TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex, modulating the γ-secretase but not the ε-secretase cleavage activity of the amyloid precursor protein (APP).
The presenilin complex includes APH1, nicastrin, and PEN2, which together cleave APP at γ- and ε-sites, potentially leading to the accumulation of the Aβ cleavage product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments have shown that TMP21 interacts with these proteins, suggesting a regulatory role in the complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Aβ production, indicating that TMP21 modulates γ-secretase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.