Thermo Fisher Scientific ULBP1 Recombinant Rabbit Monoclonal Antibody (JE65-75)
ULBP1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot에 적합합니다. HEK293 세포에서 발현되며 Protein A로 정제되었습니다. 인체 반응성, 액상 형태, 안정적인 저장 조건을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE65-75 |
| Immunogen | Synthetic peptide within human ULBP1 aa 1–50/244 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931285 |
Target Information
ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBP ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK, and PI3K/Akt signal transduction pathways.
In CMV-infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16. This interaction blocks binding to the NKG2D receptor, providing a mechanism for immune evasion. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus, preventing surface expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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