Thermo Fisher Scientific RIG-I Recombinant Rabbit Monoclonal Antibody (JE60-05)
RIG-I 단백질을 인식하는 재조합 토끼 단일클론 항체로, 인간 시료에 반응합니다. Western blot에 적합하며 HEK293 세포에서 발현되었습니다. 단백질 A로 정제된 액상 형태로, 장기 보관 시 -20°C에서 보관합니다.
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Thermo Fisher Scientific RIG-I Recombinant Rabbit Monoclonal Antibody (JE60-05)
Applications
- Western Blot (WB)
Tested Dilution: 1:500
Publications: - [참고 문헌 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE60-05 |
| Immunogen | Recombinant protein within human DDX58 aa 250–450/925 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931287 |
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in the detection of viral double-stranded RNA (dsRNA). Along with MDA5, RIG-I activates the innate immune response by recognizing viral RNA.
RIG-I responds to short dsRNAs without a 5'-triphosphate end, while MDA5 responds to long dsRNAs. Both signal through IPS-1, activating NF-kappaB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I plays a critical role in the immune response to influenza A/B, RSV, paramyxoviruses, Japanese encephalitis virus, and West Nile virus.
MicroRNA-146a negatively regulates RIG-I-dependent antiviral responses by targeting TRAF6, IRAK1, and IRAK2.
Recent studies suggest RIG-I also detects cytosolic DNA via RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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