
Thermo Fisher Scientific CD28 Monoclonal Antibody (1D5)
Human CD28 단백질을 인식하는 Mouse IgG1 모노클로날 항체로, Western blot 및 ELISA에 적합. PBS buffer에 보관되며 방부제 무첨가. T세포 활성화 연구 및 CD28 관련 면역학 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D5 |
| Immunogen | CD28 (NP_006130.1, 18–152 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GNKILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKP
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It is a cell adhesion molecule of the immunoglobulin superfamily, constitutively expressed on most peripheral blood T lymphocytes.
CD28 acts as a critical T cell co-stimulatory receptor by binding CD80 and CD86 on antigen-presenting cells, providing the second activation signal.
It prevents T cells from entering an anergic or apoptotic state.
In murine lymphoid organs and blood, all CD4+ and CD8+ T cells express CD28.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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