Thermo Fisher Scientific CD28 Monoclonal Antibody (2E6)
CD28 단백질을 타겟으로 하는 Mouse IgG1 단클론 항체로, 인간 시료에 반응합니다. Western blot 및 ELISA에 적합하며, PBS 기반 액상 형태로 보존됩니다. 친화 크로마토그래피로 정제되었으며 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E6 |
| Immunogen | CD28 (NP_006130.1, 18–152 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GNKILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKP
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein. It is a member of the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes. CD28 acts as a critical T cell costimulatory receptor by binding CD80 and CD86 on antigen-presenting cells, providing the essential second activation signal. It prevents T cells from entering an anergic or apoptotic state. In murine tissues, CD28 is expressed on all CD4+ and CD8+ T cells, with expression levels varying across thymocyte maturation stages. Dysregulation of CD28 is associated with diseases such as mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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