Thermo Fisher Scientific SDHB (Succinate Dehydrogenase B) (Pheochromocytoma Marker) Monoclonal Antibody (SDHB/2382)
SDHB 단백질을 표적하는 Thermo Fisher Scientific의 단일클론 항체로, 인체 시료에 반응하며 pheochromocytoma 마커로 사용됩니다. Western blot 및 peptide array에서 검증되었으며, 고순도 Protein A/G 정제 및 PBS 버퍼로 제공됩니다.
- 카탈로그번호
- 6390-MSM2-P1ABX
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SDHB/2382 |
| Immunogen | Recombinant fragment (around aa 165–273) of human SDHB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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