Thermo Fisher Scientific TAB2 Polyclonal Antibody
Rabbit polyclonal antibody against human TAB2 단백질로, IHC에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 인간 뇌 조직에서 양성 대조군으로 사용 가능하며, 연구용으로 적합합니다.
- 카탈로그번호
- PA534365
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid synthetic peptide near the carboxy terminus of human TAB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551717 |
Product Specific Information
- A suggested positive control is human brain tissue.
- PA5-34365 can be used with blocking peptide PEP-1408.
Target Information
TAB2 is an activator of MAP3K7/TAK1, required for IL-1 induced activation of NF-kappaB and MAPK8/JNK.
It forms a kinase complex with TRAF6, MAP3K7, and TAB1, serving as an adaptor linking MAP3K7 and TRAF6.
TAB2, TAB1, and MAP3K7 also participate in TNFSF11/RANKL-induced signal transduction through TNFRSF11A/RANK, regulating osteoclast development and function.
TAB2 and TAB3 interact with Beclin-1; upon autophagy induction, they dissociate from Beclin-1 and bind TAK1.
Overexpression of TAB2/TAB3 inhibits autophagy, while depletion triggers it, suggesting their role as control points in autophagy regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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