Thermo Fisher Scientific EpCAM/CD326 (Epithelial Marker) Monoclonal Antibody (rMOC-31)
EpCAM/CD326 단백질을 인식하는 rMOC-31 클론의 마우스 단클론 항체로, 인간 시료에 반응합니다. WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 사용 가능하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific EpCAM/CD326 (Epithelial Marker) Monoclonal Antibody (rMOC-31)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Immunomicroscopy (IM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rMOC-31 |
| Immunogen | Recombinant full-length human EpCAM protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
- Does not react with Rat, Dog or Cat.
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in epithelial tissues with a molecular weight of approximately 40 kDa.
It functions as a calcium-independent epithelial cell adhesion molecule and plays a role in regulating cell cycle, proliferation, and metabolism through induction of proto-oncogene c-myc and cell cycle genes cyclin A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial cell differentiation and growth.
Overexpression of Ep-CAM is associated with enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for tumors of epithelial lineage.
It is localized on the basolateral surface of most simple epithelia and various carcinoma types.
Ep-CAM can help distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 4072-MSM19-P1ABX_EpCAM_CD326_P16422-1_House_mouse.svg, 4072-MSM19-P1ABX_EpCAM_CD326_P16422-1_House_mouse_PDP.jpeg)
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