Thermo Fisher Scientific Ep-CAM/CD326 (Extracellular Domain) (Epithelial Marker) Monoclonal Antibody (VU-1D9), PE
Ep-CAM/CD326 단백질을 인식하는 인간 반응성 단클론 항체로, PE 형광체가 결합되어 ICC/IF 및 유세포분석에 적합합니다. 단백질 A/G로 정제되었으며, 암 및 상피세포 마커 연구에 활용됩니다. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific Ep-CAM/CD326 (Extracellular Domain) Monoclonal Antibody (VU-1D9), PE
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 5 µL/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VU-1D9 |
| Immunogen | Small cell lung carcinoma cells |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | See Label |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
Additional Formats
- Unconjugated
- Biotin
- CF 488
- Custom conjugation available upon request
Product Specific Information
- Does not react with Rat or Ferret
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial tissues. It acts as a calcium-independent cell adhesion molecule influencing cell cycle, proliferation, and metabolism by inducing proto-oncogene c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression is linked to enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for tumors of epithelial lineage.
Ep-CAM is found on the baso-lateral surface of most simple epithelia and carcinoma types, and can distinguish adenocarcinomas from pleural mesotheliomas.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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