Thermo Fisher Scientific TNPO2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human TNPO2. Validated for ICC/IF applications. Antigen affinity purified and supplied as a liquid in PBS with glycerol. Suitable for research use in nuclear transport studies.
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Applications
Immunocytochemistry (ICC/IF)
- Tested dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TNPO2. Recombinant protein control fragment (Product # RP-107820) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662040 |
Product Specific Information
Immunogen sequence:
QDIKPRFHKSR TVTLPHEAER PDGSEDAEDD DD
Highest antigen sequence identity to the following orthologs:
- Mouse: 94%
- Rat: 97%
Target Information
TNPO2 probably functions in nuclear protein import as a nuclear transport receptor. It serves as a receptor for nuclear localization signals (NLS) in cargo substrates. TNPO2 mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin, followed by energy-dependent translocation through the pore via a Ran-dependent mechanism.
At the nucleoplasmic side of the NPC, Ran binds to the importin, causing dissociation of the importin/substrate complex. Importin is then re-exported from the nucleus to the cytoplasm, where GTP hydrolysis releases Ran. The directionality of nuclear import is conferred by the asymmetric distribution of GTP- and GDP-bound Ran forms between cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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