Thermo Fisher Scientific SLC22A18 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SLC22A18 protein. Validated for IHC (paraffin) applications. Antigen affinity purified and supplied in liquid form with PBS/glycerol buffer. Ideal for research on renal and cancer-related transport mechanisms.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SLC22A18. Recombinant protein control fragment (Product #RP-107818) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2664352 |
Product Specific Information
Immunogen sequence:
PASTKGAKTDA QAPLPGGPRA SVFDLKAIAS LLRLPDVPRI
Highest antigen sequence identity to the following orthologs:
- Mouse: 54%
- Rat: 49%
Target Information
ORCTL2 (organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A or SLC22A18, is a 424 amino acid multi-pass membrane protein that localizes at the apical membrane surface of renal proximal tubules.
It is highly expressed in kidney, liver, colon, and fetal renal proximal tubules, and at lower levels in heart, brain, and lung.
Belonging to the major facilitator superfamily, ORCTL2 may act as a transporter of organic cations via a proton efflux antiport mechanism and may play a role in the transport of chloroquine and quinidine-related compounds in the kidney.
Defects in ORCTL2 are associated with breast and lung cancer and are the cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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