Thermo Fisher Scientific CYFIP2 Polyclonal Antibody
Rabbit polyclonal antibody against human CYFIP2, validated for ICC/IF. Antigen affinity purified and supplied in PBS with glycerol. Suitable for research on p53-dependent apoptosis and CYFIP family signaling.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CYFIP2. Recombinant protein control fragment (Product # RP-107817) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664376 |
Product Specific Information
Immunogen sequence:
STQACQWSPRA LFHPTGGTQG RRGCRSLLY
Highest antigen sequence identity to orthologs:
- Mouse: 100%
- Rat: 40%
Target Information
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121)
CYFIP2 is a 1,278 amino acid protein encoded by the human CYFIP2 gene. It belongs to the CYFIP family and plays a role in T-cell adhesion and p53-dependent induction of apoptosis. CYFIP2 interacts with FMR1, FXR1, and FXR2, and is part of the WAVE1 complex (Abi-2, CYFIP2, C3orf10/HSPC300, NAP125, WASF1/WAVE1).
Upon binding to activated Rac1, CYFIP2 causes dissociation of the complex, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that mediates transcriptional activation. Induced expression of CYFIP2 can trigger caspase activation and apoptosis, similar to p53 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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