Thermo Fisher Scientific ORC1 Polyclonal Antibody
ORC1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C에서 보관. DNA 복제 개시 관련 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 811 and 861 of human origin recognition complex subunit 1 (ORC1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The origin recognition complex (ORC) is a highly conserved six-subunit protein complex essential for the initiation of DNA replication in eukaryotic cells.
Studies in yeast have shown that ORC binds specifically to origins of replication and serves as a platform for the assembly of initiation factors such as Cdc6 and Mcm proteins.
The ORC1 protein is the largest subunit of the ORC complex. Unlike other ORC subunits, its levels vary throughout the cell cycle and are regulated by ubiquitin-mediated proteolysis after DNA replication initiation.
ORC1 is selectively phosphorylated during mitosis and interacts with MYST histone acetyltransferase 2 (MyST2/HBO1), which is involved in transcriptional silencing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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