Thermo Fisher Scientific SOS1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SOS1 protein for WB and IP applications. Recognizes region 1283–1333 of SOS1. Supplied as liquid, unconjugated, 0.2 mg/mL concentration. Stable for 1 year at 4°C; shipped on wet ice. Suitable for research use ...
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1283 and 1333 of Human son of sevenless ortholog 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1 and its closely related Sos2 paralog contain:
- N-terminal histone-binding domain
- RacGEF catalytic (DH) domain with adjacent PH domain
- Ras exchanger motif (REM) domain
- RasGEF catalytic domain
- C-terminal proline-rich region
Sos1 catalyzes GDP-GTP exchange within membrane-bound GTPase Ras, activating the MAPK cascade central to cellular proliferation, survival, and differentiation. Growth factor stimulation induces phosphorylation of Sos on multiple serine and threonine sites, and phosphorylation within the C-terminus by MAP/ERK kinase disrupts the Grb2-Sos complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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