Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (8516), APC
인간 IL-1 beta를 인식하는 마우스 단클론 항체로, APC 형광 표지되어 유세포분석에 적합합니다. 낮은 교차 반응성과 높은 특이성을 가지며, Protein A/G로 정제되어 안정성이 우수합니다. 4°C 보관, 암조건에서 보관 권장.
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Applications
- Flow Cytometry (Flow): 10 µL/10⁶ cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8516 |
| Immunogen | E. coli-derived recombinant human IL-1 beta/IL-1F2 (aa 117–269) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage buffer | Buffered saline solution with 0.5% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609798 |
Additional Formats
Product Specific Information
This antibody shows less than 5% cross-reactivity with recombinant mouse (rm) IL-1 beta and rpIL-1 beta and no cross-reactivity with rrIL-1 beta, rmIL-1 alpha, rhIL-1ra, rmIL-1ra, or rrIL-1 alpha.
Target Information
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into the active 17 kDa form by caspase-1 upon inflammasome activation. IL-1 beta lacks a signal peptide for classical secretion and is released via an alternative pathway. It signals through IL-1RI and IL-1RII receptors shared with IL-1 alpha, and its activity is regulated by IL-1 receptor antagonist (IL-1RA). IL-1 beta plays a key role in innate immune responses and inflammation, and elevated levels are associated with chronic inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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