Thermo Fisher Scientific Histone H3 Recombinant Rabbit Monoclonal Antibody (17H2L9)
Recombinant rabbit monoclonal antibody targeting Histone H3 for WB, IHC, and ICC applications. High specificity and sensitivity with consistent lot performance. Suitable for human and rat samples, provided in liquid form with 0.5 mg/mL concentration.
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- 702023
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- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 17H2L9 |
| Immunogen | Synthetic peptide corresponding to the N-terminal region of human Histone H3 (aa 4–11) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532514 |
Additional Formats
Product Specific Information
Since Histone H3 is highly conserved across species, this antibody may react with many other species.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Histone H3 is a DNA-binding protein found in the chromatin of all eukaryotic cells. Together with other core histones, it forms the nucleosome structure. Histones play a key role in transcription regulation, DNA repair, replication, and chromosomal stability.
The N-terminal tail of Histone H3 can undergo various post-translational modifications such as methylation, acetylation, and phosphorylation, which influence chromatin structure and cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 702023_Histone_H3_P68431-1_Rabbit.svg, 702023_Histone_H3_P68431-1_Rabbit_PDP.jpeg)
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