Thermo Fisher Scientific GPR26 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human, Gibbon, Monkey, Marmoset, Bovine, Dog, Elephant, Panda, Horse (100%);
  Mouse, Rat, Rabbit, Pig (91%);
  Stickleback (82%).
• Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.

Target Information

The G-protein-coupled receptor (GPCR) superfamily comprises approximately 600–1,000 members and represents the largest known class of molecular targets with proven therapeutic value.
GPR26 is a brain-specific orphan GPCR exhibiting constitutive activity mediated by G(s)-alpha protein, which stimulates adenylate cyclase and increases intracellular cAMP levels.

• Highest expression: amygdala, hippocampus, thalamus
• Weak expression: testis
• Down-regulated in glioblastoma
• GPR26 depletion increases fat storage in C. elegans
• Deficiency in hypothalamus linked to obesity susceptibility and metabolic disorders (glucose intolerance, hyperinsulinemia, dyslipidemia)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.