Thermo Fisher Scientific TMEM24 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TMEM24. Recombinant protein control fragment (Product #RP-90476). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TMEM24,uniProtId:O14523-1,ncbiNodeId:9606,antigenRange:302-449,antigenLength:706,antigenImageFileName:PA5-52780_TMEM24_O14523-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52780_TMEM24_O14523-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648667

Product Specific Information

Immunogen sequence: LEGTEELCCV AELDNPMQQK WTKPARAGSE VEWTEDLALD LGPQSRELTL KVLRSSSCGD TELLGQATLP VGSPSRPLSR RQLCPLTPGP GKALGPAATM AVELHYEEGS PRNLGTPTSS TPRPSITPTK KIELDRTIMP DGTIVTTV

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.

Target Information

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.