Thermo Fisher Scientific TMEM24 Polyclonal Antibody
Human TMEM24 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. Antigen affinity chromatography로 정제되어 높은 특이성과 재현성을 제공. 인산지질 수송 및 칼슘 신호 조절 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TMEM24. Recombinant protein control fragment (Product #RP-90476). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648667 |
Product Specific Information
Immunogen sequence:
LEGTEELCCV AELDNPMQQK WTKPARAGSE VEWTEDLALD LGPQSRELTL KVLRSSSCGD TELLGQATLP VGSPSRPLSR RQLCPLTPGP GKALGPAATM AVELHYEEGS PRNLGTPTSS TPRPSITPTK KIELDRTIMP DGTIVTTV
Highest antigen sequence identity to the following orthologs:
- Mouse: 91%
- Rat: 91%
Target Information
Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843).
Maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling.
Plays a key role in coordinating Ca(2+) and phosphoinositide signaling by tethering the ER and cell membrane.
Upon elevation of cytosolic Ca(2+), it becomes phosphorylated and dissociates from the membrane, halting phosphatidylinositol transport.
Positively regulates insulin secretion in response to glucose by replenishing PI(4,5)P2 pools and facilitating calcium channel opening, priming new insulin granules.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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