Thermo Fisher Scientific ARHGEF11 Polyclonal Antibody
ARHGEF11 단백질을 인식하는 토끼 다클론 항체로, Western blot과 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, 인간 시료에 반응. 세포골격 재구성 및 RhoA 신호전달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGEF11. Recombinant protein control fragment (Product #RP-89158) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638161 |
Product Specific Information
Immunogen sequence:
LQAEIDSRLR NSEDARGVLC EAQEAAMPEI QEQIHDYRTK RTLGLGSLYG ENDLLDLDGD PLRERQVAEK QLAALGDILS KYEEDRSAPM DFALNTYMSH AGIRLREARP SNTAEKAQSA PDKDKWLPFF PKTKKSSNSK KEQDA
Highest antigen sequence identity to the following orthologs:
- Mouse: 90%
- Rat: 88%
Target Information
ARHGEF11 is a 1527 amino acid protein containing tandem dbl homology and pleckstrin homology domains, a PDZ domain, two proline-rich sequences, and a regulatory G protein-signaling (RGS) sequence.
It acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase (not for RAC1 or CDC42) and as a GTPase-activating protein (GAP) for GNA12 and GNA13.
ARHGEF11 forms complexes with G proteins, mediating Rho-dependent neurite retraction signals and increasing glutamate transport fourfold.
It interacts with EAAT4, modulating uptake activity and perisynaptic distribution at glutamatergic synapses.
Overexpression induces actin cytoskeleton reorganization, membrane ruffling, and filopodia formation.
It is ubiquitously expressed in brain, lung, liver, kidney, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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